and Analysis of the Article “Scientists Reveal
Structure of Gateways to Gene Control”
The modern science has, unquestionably achieved great results,
but there are still a lot of questions to be answered and
genetics remains one of the most mysterious sciences. In order
to enlarge human knowledge about gene packaging and regulate,
scientists at Penn State University have conducted the study
which results are really important since the scientists made
several important discoveries that facilitate the further
genetic researches. In fact, the problem of gene packaging
and regulation was insufficiently research and, what is more,
the existing scientific experience did not provide ample opportunities
to conduct fast research. Moreover, the previous researches
rather provided the fragmentary information about gene packaging,
regulation and control.
The research conducted by scientists at Penn State University
targeted at the elimination of the existing problems mentioned
above and basically was focused on the enlargement of the
modern knowledge about gene packaging and regulation. To put
it more precisely, the scientists, led by B. Franklin Pugh,
professor of biochemistry and molecular biology, attempted
to investigate how a gene’s function can be turned on
in a particular cell and the role of nucleosomes in this process.
The findings the scientists made are extremely important and
significant. It should be said that the scientists revealed
the fact that there exists direct relationship between the
architecture of nucleosomes structure and the respective DNA
sequences that are regulated by these nucleosomes. Moreover,
the scientists revealed the “architecture of a critical
gateway, controlled by the nucleosome, which must be unlocked
before agene can be transcribed” (1). It is important
to underline that the scientists revel that the positioning
of the transcription of the gateway of genes that have the
same structure is similar.
Furthermore, among the most important findings and results
of the research may be named the fact that the scientists
managed to get a clear picture of the architecture of the
DNA in the control regions. Obviously, this can help better
understand how genes are actually regulated that is the question
of the survival of a living being. Also, the researchers mapped
the positions of nucleosomes across the entire genome.
In the result of the discoveries made by scientists it is
possible to estimate that the further researches have received
a very important basis that can increase their effectiveness.
To put it more precisely, the better understanding of gene
regulation and new methodology of DNA sequences provide an
opportunity to sequence DNA strands at enormous amount up
to hundreds of thousands that has been impossible before.
Moreover, nowadays, scientists have a clearer picture of the
architecture of DNA that will naturally be very important
to the further researches, especially concerning the research
of gene control and regulation since the DNA control regions
were thoroughly researched by scientist.
Thus, in conclusion, it is possible to say that the research
conducted by the scientists at Penn State University have
provided the researchers with ample information about gene
control and regulation and opened the way to more effective
1. Scientists Reveal Structure of Gateways to Gene Control.
Retrived April 15, 2007 from <http://www.sciencedaily.com/releases/2007/03/070328155639.htm>